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THE PATHOPHYSIOLOGY OF THE ENDOTHELIUM: MOVING FROM 2D TO 3D CULTURE AND BEYOND
Vol 32, Issue 4S1, 2018
Abstract
Vascular endothelial cells (ECs) line the entire circulatory tree. In spite of their well knownheterogeneity, ECs display a myriad of fundamental homeostatic functions such as keeping bloodfluid, regulating blood flow, regulating macromolecule and fluid exchange with the tissues, preventingleukocyte and platelet activation, and participating in immune surveillance. Most of present knowledgehas been achieved using 2D monolayer cell culture systems. However, they do not accurately recapitulatethe structure and function of living tissues. To bridge the gap between classical 2D cell culture and invivo models, 3D culture techniques have been generated.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy