PHAGOCYTOSIS OF DIFFERENT STAGES OF PLASMODIUM FALCIPARUM GAMETOCYTES BY BONE MARROW MACROPHAGES

Y. CORBETT; ALESSANDRO; S. PARAPINI; V. MESSINA; F. SILVESTRINI; N. BASILICO; D. TARAMELLI

doi:10.54517/jbrha6497

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

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PHAGOCYTOSIS OF DIFFERENT STAGES OF PLASMODIUM FALCIPARUM GAMETOCYTES BY BONE MARROW MACROPHAGES

Article ID: 6497
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6497

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Gametocytes (GCT), the sexual stage of malaria parasites, develop in five stages (I-V). Stages I-IVare predominantly sequestered and differentiate in the extravascular compartment of the bone marrow,while stage V are released in the circulation from where they are taken up by a mosquito during a bloodmeal, causing malaria transmission. Few information are available about the role of the innate immunityagainst GCT. The aim of this work was to set up a model to study of the ability of P. falciparum (Pf) GCTto activate and be phagocytised by bone marrow macrophages.

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Medical Genetics, University of Torino Medical School, Italy

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