EFFECT OF OXYGEN LOADED NANODROPLETS ON HUMAN ENDOTHELIAL CELLS AND MACROPHAGES CULTURED IN NORMOXIC VERSUS HYPOXIC CONDITIONS

F. PEREGO; S.; P. MISIANO; S. TURINI; A. TROIA; M. PRATO; D. TARAMELLI; N. BASILICO

doi:10.54517/jbrha6495

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

EFFECT OF OXYGEN LOADED NANODROPLETS ON HUMAN ENDOTHELIAL CELLS AND MACROPHAGES CULTURED IN NORMOXIC VERSUS HYPOXIC CONDITIONS

Article ID: 6495
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6495

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Chronic wounds are an emerging issue in Western countries, but their pathogenetic mechanismshave not been clarified, yet. Oxygen availability is crucial for tissue healing. Thus, hypoxia is detrimentalin chronic wounds and new oxygen-based therapies should be investigated. Here, oxygen-loadednanodroplets (OLND) with an oxygen-binding fluorocarbon (2H, 3H-decafluoropentane) in the innercore and dextran or chitosan in the outer shell are proposed as carriers of oxygen to the hypoxic milieu,to counteract the effects of hypoxia in wound healing.

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