THE COENZYME Q10 AS COUNTERMEASURE FOR RETINAL DAMAGE ONBOARD THE INTERNATIONAL SPACE STATION: THE CORM PROJECT

M. LULLI; F. CIALDAI; L. VIGNALI; M. MONICI; S. LUZZI; A. CICCONI; S. CACCHIONE; A. MAGI; M. BALSAMO; M. VUKICH; G. NERI; A. DONATI; S. CAPACCIOLI

doi:10.54517/jbrha6491

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

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THE COENZYME Q10 AS COUNTERMEASURE FOR RETINAL DAMAGE ONBOARD THE INTERNATIONAL SPACE STATION: THE CORM PROJECT

M. LULLI, F. CIALDAI, L. VIGNALI, M. MONICI, S. LUZZI, A. CICCONI, S. CACCHIONE, A. MAGI, M. BALSAMO, M. VUKICH, G. NERI, A. DONATI, S. CAPACCIOLI

Article ID: 6491
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6491

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Cells, tissues and organs of astronauts aboard the International Space Station (ISS) are exposedto the damaging effects of microgravity and cosmic radiation. Space Agencies are forced to findeffective therapeutic countermeasures to safeguard astronauts’ health. Since retina is one of the mostvulnerable target, we undertook a project entitled The Coenzyme Q10 (CoQ10) as countermeasurefor retinal damage onboard the International Space Station: the CORM project, funded by the ItalianSpace Agency (ASI) and launched in the summer 2017. We selected CoQ10 as promising candidatedrug, having previously first demonstrated its direct antiapoptotic property due to its ability to inhibitmitochondrial depolarization.

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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