PARAMETERS OF EPITHELIAL-MESENCHYMAL TRANSITION AS PREDICTORS OF CANCER AGGRESSIVENESS

S. DINICOLA; R. VERNA; A. CUCINA; M. BIZZARRI

doi:10.54517/jbrha6490

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

PARAMETERS OF EPITHELIAL-MESENCHYMAL TRANSITION AS PREDICTORS OF CANCER AGGRESSIVENESS

S. DINICOLA, R. VERNA, A. CUCINA, M. BIZZARRI

Article ID: 6490
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6490

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Cancer cell transition from a low-invasive phenotype into a more malignant one constitutes a criticalevent during tumor progression. The Epithelial-Mesenchymal Transition (EMT) occurring in solid cancersis at the core of such transformation. A recurrent metaphor for the complex developmental path of cellsystems across different phenotypic states is given by the Waddington landscape in which cell phenotypesare depicted as stable attractors, while metastable or unstable states represent unstable attractors.

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

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