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LOCAL ENDOTHELIAL ACTIVATION AND CONTRIBUTION TO ESTABLISHMENT OF LEISHMANIA SPP INFECTION
Vol 32, Issue 4S1, 2018
Abstract
Leishmaniasis comprises a group of neglected vector-borne diseases caused by intracellularprotozoa of the genus Leishmania. The promastigotes are deposited into the human skin by the biteof phlebotomine sandflies and internalized by phagocytic cells where they develop into amastigotes,multiply and cause the cutaneous or visceral disease. Neutrophils, immediately recruited to the bitesite, phagocytize Leishmania promastigotes, which elude the neutrophils killing mechanisms and infectmacrophages. Although endothelial cells represent one of the first cells type encountered by Leishmaniapromastigotes, little is known on their role in the establishment of the infection. Here, the interactionbetween human endothelial cells and Leishmania promastigotes was studied.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy