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ROLE OF THE TRANSCRIPTION FACTOR YIN YANG 1 IN CANCER
Vol 32, Issue 4S1, 2018
Abstract
Yin Yang 1 (YY1) is transcription factor ubiquitously expressed, able to either activate or represstranscription through direct or indirect interaction with the chromatin. YY1 is thought to be involvedin the modulation of a large number of mammalian genes. The ability of this DNA binding proteinto promote or inhibit gene expression depends on its specific target sequence, chromatin structure aswell as its specific protein interactors. YY1, found expressed at different levels in many cancer types,has been seen to have the effect of either stimulating or inhibiting cancer growth. The mechanism(s)responsible for such diverging effects needs to be further clarified.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy