FLAGELLAR MOTILITY REDUCTION IN LISTERIA MONOCYTOGENES AFTER TREATMENT WITH CANNABIS SATIVA L. ESSENTIAL OIL

E. MARINI; G. MAGI; A. GIULIANI; V. DE DOMINICIS; M. PAVANI; M.R. RIPPO; A. PUGNALONI; B. FACINELLI

doi:10.54517/jbrha6484

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

FLAGELLAR MOTILITY REDUCTION IN LISTERIA MONOCYTOGENES AFTER TREATMENT WITH CANNABIS SATIVA L. ESSENTIAL OIL

E. MARINI, G. MAGI, A. GIULIANI, V. DE DOMINICIS, M. PAVANI, M.R. RIPPO, A. PUGNALONI, B. FACINELLI

Article ID: 6484
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6484

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

A major group of plant antimicrobial compounds is represented by essential oils (EOs), complexmixtures of volatile secondary metabolites belonging to different chemical families. Cannabis sativa L.has been grown for thousands of years for a multiplicity of purposes; in recent years, some genotypescontaining low cannabinoid concentrations have been selected and used for research purposes. Listeriamonocytogenes is a facultative intracellular food pathogen, mobile for the presence of several flagella.In humans, the treatment of listeriosis is hampered by the intracellular location of listeriae and thepoor intracellular penetration of some antibiotics. Flagellum-based motility has been implicated invirulence since it is critical for initial surface attachment. The purpose of this study was to investigate theantibacterial and anti-virulence properties of an EO extracted from a legal C. sativa L. variety against aclinical isolate of L. monocytogenes.

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Medical Genetics, University of Torino Medical School, Italy

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