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THE MOLECULAR CROSS-TALK AMONG ARG/ABL2, TGF-b1 AND LOX IN CLEAR CELL RENAL CELL CARCINOMA PROGRESSION
Vol 32, Issue 4S1, 2018
Abstract
An involvement of TGF-b1 in promoting bone metastases affecting about 30% of clear cell Renal CellCarcinoma (ccRCC) patients was described. The extracellular matrix enzyme Lysyl oxidase (Lox) throughosteoclast activation and osteoblast inhibition induces pre-metastatic bone lesions in breast and coloncancer. We evidenced Lox overexpression in ccRCC and TGF-b1 production modulated by Arg tyrosinekinase in renal tubular cells. Arg modulates invasion and metastasis of breast and prostate cancer throughcytoskeleton regulation. These data suggest that Arg, TGF-b1 and Lox might interact to promote tumorinvasion and metastasis. Here we analyse the molecular and functional interactions among Arg, TGF-b1and Lox in ccRCC and their effects on osteoclast and osteoblast pre-metastatic functions.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy