Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.
JAGGED1/2 INHIBITION PROMOTES MULTIPLE MYELOMA CELL SENSITIVITY TO BORTEZOMIB IN VITRO, EX VIVO AND IN VIVO IN A NOVEL ZEBRAFISH MODEL
Vol 32, Issue 4S1, 2018
Abstract
Multiple myeloma (MM) is the second most diffuse hematological malignancy and nowadays is stillincurable, despite the development of innovative therapies. MM cells accumulate in the bone marrow(BM) and establish vicious interactions with the surrounding normal cells, inducing them to promotetumor progression and the development of drug resistance. In this process, a crucial role is played bythe dyregulated Notch ligands Jagged1 and 2, whose overexpression boosts Notch both in MM cellsand in the BM cells. Here, we investigated how Jagged1/2 inhibition affects MM cells resistance to thestandard-of-care drug Bortezomib.
References
Supporting Agencies
Copyright (c) 2018 M. COLOMBO, M. MAZZOLA, N. PLATONOVA, S. GARAVELLI, M.T. PALANO, M. BARBIERI, D. GIANNANDREA, E. LAZZARI, A. BASILE, A. PISTOCCHI, A. NERI, R. CHIARAMONTE
This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy