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ROLE OF 1ALCTL AND 1BLCTL ARG ISOFORMS IN THE FIBROBLAST ACTIVATION
Vol 32, Issue 4S1, 2018
Abstract
The excessive scar tissue deposition of fibrotic process and the tumor stroma have in the activatedfibroblasts (myofibroblasts) the main players. Myofibroblasts remodel the extra cellular matrix (ECM)by specialised cytoskeletal contractile features (stress fibres and focal adhesions) that reorganise thesupportive tumour stroma. The non-receptor tyrosine kinase Arg binds directly to the cytoskeletontransducing extracellular signals into cytoskeletal rearrangements. ARG, through alternative splicingevents, codes eight Arg isofoms that differently modulate stress fibers and motility. We analysed therole of 1ALCTL and 1BLCTL Arg isoforms in fibroblast activation using Arg KO murine embryonalfibroblast (MEF).
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Copyright (c) 2018 B. TORSELLO, S. DE MARCO, S. BOMBELLI, V. CASSINA, E. CHISCI, C. BIANCHI, R. PEREGO
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Medical Genetics, University of Torino Medical School, Italy

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy