ROLE OF 1ALCTL AND 1BLCTL ARG ISOFORMS IN THE FIBROBLAST ACTIVATION

B. TORSELLO, S. DE MARCO, S. BOMBELLI, V. CASSINA, E. CHISCI, C. BIANCHI, R. PEREGO

Article ID: 6479
Vol 32, Issue 4S1, 2018
DOI: https://doi.org/10.54517/jbrha6479
Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

The excessive scar tissue deposition of fibrotic process and the tumor stroma have in the activatedfibroblasts (myofibroblasts) the main players. Myofibroblasts remodel the extra cellular matrix (ECM)by specialised cytoskeletal contractile features (stress fibres and focal adhesions) that reorganise thesupportive tumour stroma. The non-receptor tyrosine kinase Arg binds directly to the cytoskeletontransducing extracellular signals into cytoskeletal rearrangements. ARG, through alternative splicingevents, codes eight Arg isofoms that differently modulate stress fibers and motility. We analysed therole of 1ALCTL and 1BLCTL Arg isoforms in fibroblast activation using Arg KO murine embryonalfibroblast (MEF).



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