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INVOLVEMENT OF ANNEXIN A3 ISOFORMS IN MODULATION OF LIPID STORAGE INTO CLEAR CELL RENAL CELL CARCINOMA (CCRCC) CELLS
Vol 32, Issue 4S1, 2018
Abstract
ccRCC cells show an adipocyte-like morphology due to neutral lipid accumulation. The molecularmechanism responsible for this phenotype has yet to be clarify. Notably, ccRCC cells show a geneexpression signature consistent with adipogenesis and can undergo adipogenic transdifferentiation.The Ca2+-dependent phospholipid-binding praotein Annexin A3 (AnxA3) has been recently described asnegative regulator of adipocyte differentiation. In RCC, we evidenced that AnxA3 is downregulated andshows a specific pattern of two isoforms of 36 and 33 kDa originated by an alternative splicing event.In the current study, we have investigated the role of AnxA3 isoforms in the modulation of lipid storageresponsible of the adipocyte-like morphology of ccRCC cells.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy