NOTCH 1 PATHWAY AND EPCS IN BICUSPID AORTIC VALVE: IS THEIR INTERPLAY INVOLVED IN THE ASCENDING AORTIC ANEURYSM ONSET?

C.R. BALISTRERI, F. CRAPANZANO, A. ALLEGRA, C. PISANO, G. RUVOLO, D. LIO, L. SCHIRONE, E. CAVARRETTA, S. SCIARRETTA, G. FRATI

Article ID: 6475
Vol 32, Issue 4S1, 2018
DOI: https://doi.org/10.54517/jbrha6475
Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Bicuspid aortic valve (BAV) is frequently associated with development of ascending aortic aneurysm,even if the underlying mechanisms remain to be clarified. Here, we investigated if a deregulation ofNotch1 signaling pathway and endothelial progenitor cells (EPCs) number is associated with BAVdisease and an early ascending aortic aneurysm (AAA) onset.



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Copyright (c) 2018 C.R. BALISTRERI, F. CRAPANZANO, A. ALLEGRA, C. PISANO, G. RUVOLO, D. LIO, L. SCHIRONE, E. CAVARRETTA, S. SCIARRETTA, G. FRATI




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