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NOTCH 1 PATHWAY AND EPCS IN BICUSPID AORTIC VALVE: IS THEIR INTERPLAY INVOLVED IN THE ASCENDING AORTIC ANEURYSM ONSET?
Vol 32, Issue 4S1, 2018
Abstract
Bicuspid aortic valve (BAV) is frequently associated with development of ascending aortic aneurysm,even if the underlying mechanisms remain to be clarified. Here, we investigated if a deregulation ofNotch1 signaling pathway and endothelial progenitor cells (EPCs) number is associated with BAVdisease and an early ascending aortic aneurysm (AAA) onset.
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Copyright (c) 2018 C.R. BALISTRERI, F. CRAPANZANO, A. ALLEGRA, C. PISANO, G. RUVOLO, D. LIO, L. SCHIRONE, E. CAVARRETTA, S. SCIARRETTA, G. FRATI
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Medical Genetics, University of Torino Medical School, Italy

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy