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IDENTIFICATION OF NEW BIOMARKERS FOR CARDIAC DISORDERS EXPLOITING TISSUE-SPECIFIC METHYLATION PATTERN OF CIRCULATING FREE DNA: A PILOT STUDY
Vol 32, Issue 4S1, 2018
Abstract
Cardiomyopathies are a group of diseases leading to adverse outcome. Due to clinical heterogeneity andphenotypic overlapping, the identification of specific non-invasive diagnostic and prognostic markerscan be useful and remains a challenge. Our aim is to exploit cardiac cfDNA as new cardiac biomarkerbased on the following assumptions: i) methylation patterns are unique and conserved in a specifictissue, hence their analysis could be used to identify the tissue of origin of circulating cell free DNA(cfDNA); ii) cfDNA levels of cardiac origin may be higher in the presence of cardiac disorder.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy