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ESTROGENIC GPER SIGNALING PROMOTES FGF2/FGFR1 ACTIVATION BETWEEN BREAST CANCER-ASSOCIATED FIBROBLASTS (CAFS) AND TUMOR CELLS
Vol 32, Issue 4S1, 2018
Abstract
Many cancers acquire aberrant growth and invasion capacity through the dysregulation of fibroblastgrowth factors (FGFs)-mediated signaling (Carter EP, Trends Cell Biol. 2015). In particular, FGFs secretedby the tumor cells or stromal compartment activate the cognate receptors leading to cancer progression(Babina IS, Nat Rev Cancer. 2017). For instance, FGF2-FGFR1 autocrine and/or paracrine loop activationhas been involved in the migration and invasion of cancer cells (Coleman SJ, EMBO Mol. Med. 2014).Remarkably, estrogens induced via the estrogen receptor (ER) the up-regulation and secretion of FGF2in breast and lung cancer (Fillmore CM, PNAS. 2010, Siegfried JM, Oncotarget. 2017). Likewise, the Gprotein estrogen receptor (GPER) was also involved in the regulation of FGF2 by estrogens toward theactivation of downstream signaling pathways in astroglial cells (Huang C, Neuroscience. 2016).
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy