
Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

ROLE OF ANDROGEN RECEPTOR IN BREAST CANCER-ASSOCIATED FIBROBLASTS: MAY ANDROGEN SHAPE BREAST TUMOR MICROENVIRONMENT?
Vol 32, Issue 4S1, 2018
Abstract
Interaction between breast tumor epithelial and stromal cells is central for tumor growth and progression.Indeed, while providing a scaffold for the breast, the stroma also regulates epithelial cell function throughphysical and hormonal paracrine exchanges, providing a favorable environment for proliferation andmetastasis. There is extensive knowledge of androgen receptor (AR) signaling in breast epithelial cancercells, but less regarding AR-mediated action in breast tumor stroma. In the present report, we provideevidence of AR expression in breast cancer-associated fibroblasts (CAFs) isolated from breast cancerpatients. We also examined the effect of CAFs exposure to androgens on: 1) secretory phenotype and 2) themigratory behavior of the estrogen-responsive breast cancer MCF-7, T47D and ZR-75 cells.
References
Supporting Agencies
Copyright (c) 2018
This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Medical Genetics, University of Torino Medical School, Italy

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy