ROLE OF ANDROGEN RECEPTOR IN BREAST CANCER-ASSOCIATED FIBROBLASTS: MAY ANDROGEN SHAPE BREAST TUMOR MICROENVIRONMENT?


Article ID: 6470
Vol 32, Issue 4S1, 2018
DOI: https://doi.org/10.54517/jbrha6470
Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Interaction between breast tumor epithelial and stromal cells is central for tumor growth and progression.Indeed, while providing a scaffold for the breast, the stroma also regulates epithelial cell function throughphysical and hormonal paracrine exchanges, providing a favorable environment for proliferation andmetastasis. There is extensive knowledge of androgen receptor (AR) signaling in breast epithelial cancercells, but less regarding AR-mediated action in breast tumor stroma. In the present report, we provideevidence of AR expression in breast cancer-associated fibroblasts (CAFs) isolated from breast cancerpatients. We also examined the effect of CAFs exposure to androgens on: 1) secretory phenotype and 2) themigratory behavior of the estrogen-responsive breast cancer MCF-7, T47D and ZR-75 cells.



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