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ADIPOCYTE-RELEASED FACTORS AFFECT VIABILITY, MIGRATION AND RESPONSE TO DOCETAXEL IN PROSTATE CANCER CELLS
Vol 32, Issue 4S1, 2018
Abstract
The prevalence of obesity is increasing at an alarming rate in developed countries throughout theworld. Epidemiologic studies indicate that obesity is important risk factors for diabetes, cardiovasculardisease and cancer. In particular, obesity is associated with a greater increase of aggressive prostatecancer (PCa) with increased local dissemination. Prostatic gland is surrounded by periprostatic adiposetissue (PPAT). PPAT is an active endocrine organ able to secrete molecules known as adipokines. Thehigh prevalence of both obesity and PCa highlights the importance of understanding the biologicalfeatures of this relationship. Recent studies uncovered that the secretion of mature adipocytes can affectthe early stage of PCa progression by promoting the spread of cancer cells outside the prostate gland. It isclear that tumor-surrounding adipocytes might affect cancer phenotype, but the molecular mechanismsinvolved in this cross-talk are still unknown.
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Copyright (c) 2018 A. LIOTTI, E. LA CIVITA, D. LIGUORO, L. DE STEFANO, A. PALMIERI, V. MIRONE, F. BEGUINOT, P. FORMISANO, D. TERRACCIANO
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy