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THE METABOLIC MICROENVIRONMENT IMPOSED BY GLUTAMINE SYNTHETASENEGATIVE MULTIPLE MYELOMA CELLS SHAPES THE BONE MARROW NICHE
Vol 32, Issue 4S1, 2018
Abstract
Altered cancer metabolism satisfies high demand for nutrients but also has an impact on non-cancercells of tumor microenvironment. In the bone marrow (BM) of multiple myeloma (MM) patients,glutamine (Gln) is lowered, while glutamate (Glu) and ammonium increase (Bolzoni, Chiu et al.,Blood 2016; 128:667-679). Glutamine Synthetase (GS), which catalyzes Gln synthesis from Glu andammonium, is lowered in most MM cells and down-regulated during osteoblastogenesis. Since bonelesions of MM patients are characterized by low osteoblast viability and function, we hypothesize thatMM cells negatively affect osteoblastogenesis through the peculiar low-Gln, high-Glu bone marrowmicroenvironment.
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Supporting Agencies
Copyright (c) 2018 M. CHIU, D. TOSCANI, M. BOLZONI, G. TAURINO, F. ACCARDI, N. GIULIANI, O. BUSSOLATI
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy