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A NEW DOWEL IN ENDOTHELIAL ADAPTATION TO MICROGRAVITY: IMPACT ON MITOCHONDRIA
Vol 32, Issue 4S1, 2018
Abstract
Blood vessels are lined by cells (ECs) that are crucial to maintain vascular and tissue homeostasis.Endothelial function is shaped by mechanical forces, i.e. shear stress and gravity (1G). Since life evolvedunder the influence of the earth’s gravitational pull, it is not surprising that microgravity activatesadaptive responses that impact also on the endothelium. Several studies have shown that real andsimulated microgravity affect ECs behaviour in different aspects but very little is known about themetabolic adaptation of these cells. In particular, we focused our attention on the mitochondria, rodshapedorganelles that convert oxygen and nutrients into adenosine triphosphate (ATP).
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy