HLA-B51 ALLELE CORRELATION WITH AUTOIMMUNE DISEASES OTHER THAN BEHÇET’S: A RETROSPECTIVE ANALYSIS

G. DI SPIGNA, B. COVELLI, M.R. SANSONE, M.P. OTTAVIANO, P. PALMIERI, E. DE MARINIS, A. SANGERMANO, G. BENINCASA, L. POSTIGLIONE

Article ID: 6460
Vol 32, Issue 4S1, 2018
DOI: https://doi.org/10.54517/jbrha6460
Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Behçet’s Disease (BD) is a systemic vasculitis, prevalent in males, with a chronic and inflammatorycourse and with multi-organ involvement. Are affected young subjects (20-30 years). The etiologyremains unknown but appears to be mediated by exogenous factors (bacterials or virals) that, throughimmunopathological mechanisms, start humoral or cellular responses. The main clinical manifestationsare represented by: oral ulcers, genital ulcers, cutaneous, ocular, articular, vascular and neurologicalinvolvement. Frequent is the association (about 72%) with HLA-B51 histocompatibility antigen, whichsuggested that the disease is present, following external factors, in genetically predisposed patients. HLA(Human Leukocyte Antigen) is a highly polymorphic gene with different haplotypes that can agree theresponse of the human adaptive immune system or predispose individuals to a particular immune systemdisease. The diagnostic utility of HLA-B51, associated with Behçet’s disease, has been clearly identified;however, its correlation with other autoimmune diseases has not yet been clarified. This study evaluatethe presence of the HLA-B51 allele with other autoimmune diseases.



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