MESOPOROUS SILICA NANOPARTICLES AS A VEHICLE FOR HIGHLY SELECTIVE DELIVERY OF BORTEZOMIB TO FOLATE RECEPTOR EXPRESSING CANCER CELLS

M. PELLEGRINO; A. NIGRO; E. RICCI; M. GRECO; A.; I. PERROTTA; A. LEGGIO; L. PASQUA; D. SISCI; C. MORELLI

doi:10.54517/jbrha6458

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

MESOPOROUS SILICA NANOPARTICLES AS A VEHICLE FOR HIGHLY SELECTIVE DELIVERY OF BORTEZOMIB TO FOLATE RECEPTOR EXPRESSING CANCER CELLS

Article ID: 6458
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6458

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

The major limitation of traditional chemotherapeutic agents is their poor selectivity for cancer cellsand their severe toxicity to normal cells. Therefore, localized drug delivery would, ideally, improve thetherapeutic efficacy, minimizing side effects. The properties of mesoporous silica nanoparticles (MSNs)seem to cope with this aim. A MSN-based device, FOL-MSN-BTZ, bearing the antineoplastic drugbortezomib (BTZ), linked to MSNs by means of a pH-sensitive bond and the folic acid (FOL, a targetingfunction), was then developed and tested on folate receptor (FR+ cells) overexpressing cancer cells andon FR- normal cells, in order to investigate MSNs behaviouor.

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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