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ERK5 inhibition elicits cellular senescence in human melanoma cells
Vol 32, Issue 4S1, 2018
Abstract
Extracellular signal-Regulated Kinase 5 (ERK5) is a member of the Mitogen Activated Protein Kinase (MAPK) family. ERK5 is activated by MEK5 in response to numerous stimuli and is involved in several cellular processes including the proliferation of both normal and neoplastic cells. We previously demonstrated that ERK5 is required for the proliferation of melanoma cells, a neoplasia that, especially in the advanced stages, has a very poor prognosis. Human melanomas are frequently characterized by the loss or the reduced expression of markers of cellular senescence that results in tumor growth and progression. We evaluated the effects of the inhibition of the MEK5-ERK5 pathway on cellular senescence in melanoma cells.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy