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Nucleo-cytoplasmic shuttling of progesterone receptor and cell cycle progression of breast cancer cells
Vol 32, Issue 4S1, 2018
Abstract
Progesterone receptors (PRs) belong to the steroid receptor superfamily and regulate development, growth and transformation of breast tissues. Different mechanisms, such as ligand binding, posttranscriptional modifications, interaction with signalling effectors or scaffold proteins control the steroid receptor subcellular localization, thereby influencing their activity. Derangement of steroid receptor import/export process often causes receptor delocalization and proliferative diseases of target tissues, such as breast and prostate. However, while the mechanism of steroid receptor nuclear import is well documented, the mechanism of their nuclear export is still unclear.
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Copyright (c) 2018 G Galasso, E Di Zazzo, M Di Donato, P Giovannelli, B Perillo, A Migliaccio, G Castoria
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy