A LARGE BIOMARKER INVESTIGATION IN YOUNG ASYMPTOMATIC PATIENTS WITH CEREBRAL SMALL VESSEL DISEASE IDENTIFIES ADMA AS A POSSIBLE KEY MOLECULE DRIVING ENDOTHELIAL DAMAGE


Article ID: 6449
Vol 32, Issue 4S1, 2018
DOI: https://doi.org/10.54517/jbrha6449
Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Cerebral small vessel disease (CSVD), detected as white matter hyperintensities (WMH) on brainMRI, could be a distinct pathological entity within cerebrovascular diseases. The increasing use of MRIhas lead to more incidental finding also in young people without classical vascular risk factor. The purposeof this work was to investigate different pathways implicated in endothelial dysfunction (inflammation,autoimmunity, coagulation, nitric oxide pathway) in a well selected, homogeneous population of patientswith WMH, without significant vascular risk factors or neurological diseases.



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