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A LARGE BIOMARKER INVESTIGATION IN YOUNG ASYMPTOMATIC PATIENTS WITH CEREBRAL SMALL VESSEL DISEASE IDENTIFIES ADMA AS A POSSIBLE KEY MOLECULE DRIVING ENDOTHELIAL DAMAGE
Vol 32, Issue 4S1, 2018
Abstract
Cerebral small vessel disease (CSVD), detected as white matter hyperintensities (WMH) on brainMRI, could be a distinct pathological entity within cerebrovascular diseases. The increasing use of MRIhas lead to more incidental finding also in young people without classical vascular risk factor. The purposeof this work was to investigate different pathways implicated in endothelial dysfunction (inflammation,autoimmunity, coagulation, nitric oxide pathway) in a well selected, homogeneous population of patientswith WMH, without significant vascular risk factors or neurological diseases.
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Medical Genetics, University of Torino Medical School, Italy

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy