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The keratinocyte differentiation induced by FGFR2b requires sequential involvement of PKCa and PKCd
Vol 32, Issue 4S1, 2018
Abstract
The fibroblast growth factor receptors (FGFRs) are receptor tyrosine kinases expressed, by tissuespecific alternative splicing, in epithelial IIIb or mesenchymal IIIc isoforms and controlling key physiological processes, such as cell proliferation, differentiation, survival and migration. We have previously demonstrated that the tumor suppressor epithelial isoform of the FGFR2 (FGFR2b) induces early differentiation of human keratinocytes. Since protein kinases C (PKCs) are known to regulate the differentiation program in several cellular contexts, including keratinocytes, aim of our present study was to clarify if FGFR2b could play a role also in the late steps of keratinocyte differentiation and to assess if this receptor-induced process would involve PKC isoforms.
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Supporting Agencies
Copyright (c) 2018 R Danilo, M Nanni, B Rosato, M R Torrisi, F Belleudi
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy