Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.
The role of tumor-derived exosomes in cancer immune evasion mediated by toll-like receptor 4 activation
Vol 32, Issue 4S1, 2018
Abstract
Although, it is widely recognized that cancer cells actively utilize exosomes to promote tumor growth and metastasis, the biology of tumor-derived exosomes (TEX) is incompletely understood and much remains to be study in order to define the molecular and genetic mechanism by which exosomes operate in cancer. Increased expression and activity of toll-like receptor 4 (TLR4) in chronic infectious and inflammatory conditions is associated with cancer progression: its activation induces an inflammatory signaling that increases the tumorigenic potential of cancer cells promoting their immune evasion. The purpose of this study is to investigate the immunosuppressive properties of TEX released upon TLR4 activation.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy