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ST2 fibro-citokine and IL-33 alarmin protein are expressed in obese fa/fa- Zucker rat model and correlated with pro-fibrotic gene pathways
Vol 32, Issue 4S1, 2018
Abstract
The function of ST2 fibro-mediator and IL-33 alarmin protein has been mainly investigated on immunological aspects, but recent data suggest that this pathway plays also an important role in cardiovascular system and adipose tissue inflammation. Whereas IL-33 has been demonstrated to exert anti-inflammatory and protective effects, circulating ST2 (sST2) has emerged as a prognostic biomarker in patients with myocardial infarction and heart failure. Furthermore, the IL-33/ST2 expression system is increased in severe obesity, although its role in the pathogenesis of detrimental cardiac remodeling associated with obesity is still not well defined. The aim of this study is to investigate the molecular pattern of IL-33/ST2 system and profibrotic genes activation in experimental model of obese fa/fa- Zucker rat model.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy