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UPAR function in melanoma derived-exosomes: pro-angiogenic effects on ECFCs
Vol 32, Issue 4S1, 2018
Abstract
Tumor-derived exosomes are emerging mediators of tumorigenesis. Exosomes are small membrane vesicles (40-150nm) derived from the luminal membranes of multivesicular bodies, and are released via fusion with the cell membrane. Exosomes mediate local and systemic cell communication through the horizontal transfer of information (mRNAs, microRNAs and proteins). It is well recognized that uPAR, is one of the main systems involved in tumor invasion and metastasis. Several malignant tumors show a positive correlation between uPAR levels and a more aggressive phenotype together with a poor prognosis. We have showed that uPAR is strongly upregulated in A375 and in metastasis-prone A375M6 melanoma cells with respect to normal melanocytes. Here we explored the uPAR function in melanomaderived exosomes and their pro-angiogenic capacity in ECFCs (Endothelial Colony Forming Cells).
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy