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SRAGE: a prognostic factor for mortality in end-stage renal disease patients on dialysis
Vol 32, Issue 4S1, 2018
Abstract
End stage renal disease patients on dialysis (CKD-G5D) have a high mortality rate mainly due to cardiovascular diseases (CVD). In addition to traditional CVD risk factors, which are common in these patients, excessive oxidative stress, uremia and chronic inflammation may further increase the production of advanced glycation end-products (AGEs) which in turn promote CVD and CVD-related morbidity and mortality. Much attention has been paid recently to the soluble receptor for AGEs (sRAGE) as a marker of inflammation, oxidative stress, atherosclerosis and heart failure (HF) in CKD-G5D. However, its relationship with patient outcomes is still debated.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy