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Upregulation of circulating levels of receptor for advanced glycation end products (sRAGE) in obese rats may protect against ectopic fat accumulation in the heart
Vol 32, Issue 4S1, 2018
Abstract
Receptor for advanced glycation end-products (receptor for AGEs, RAGE) is a cell-surface protein identified as a receptor for AGEs. RAGE activation mainly induces oxidative stress and inflammation. Indeed, in different organs, such as the adipose tissue and the liver, RAGE engagement has also been shown to promote lipid accumulation. Besides the cell-membrane form, RAGE exists as a soluble circulating molecule (sRAGE), a decoy receptor able to prevent the detrimental effects of AGEs at cellular level. As most of the obesity-related complications are due to the ectopic fat accumulation and no data are available about RAGE, sRAGE and heart steatosis, our aim was to explore any potential association of these molecules with heart steatosis in obesity.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy