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THE EFFECT OF THE HYPOXIC MICROENVIRONMENT ON GLIOBLASTOMA CELLS: BK CHANNELS BLOCKADE AS A NOVEL STRATEGY TO LIMIT DRUG RESISTANCE
Vol 32, Issue 4S1, 2018
Abstract
Glioblastomas (GBMs) are brain tumors of glial origin characterized by a heavy hypoxicmicroenvironment, which correlates with tumor aggressiveness. GBM cells abundantly express largeconductance,calcium-activated potassium (BK) channels and, since hypoxia modulates their activity inGBM cells, the aim of the present work was to explore their role in the hypoxia-induced chemoresistanceand to better understand the molecular mechanisms underlying the effect of the hypoxic microenvironmenton BK channels-dependent drug resistance of GBM cells.
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Copyright (c) 2018 P. ROSA, G. MANGINO, F. FAZI, S. MASCIARELLI, S. SCIARRETTA, G. MINCIONE, V. PETROZZA, G. RAGONA, A. CALOGERO
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy