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ITCH/a-ARRESTIN2-DEPENDENT NON-PROTEOLYTIC UBIQUITYLATION OF SUFU CONTROLS HEDGEHOG SIGNALLING AND MEDULLOBLASTOMA TUMORIGENESIS
Vol 32, Issue 4S1, 2018
Abstract
Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma (MB), is a centralplayer of Hh signalling, a crucial pathway for development and deregulated in tumours. Althoughthe control of Gli transcription factors by SuFu is critical in Hh pathway, our understanding of themechanism regulating this key event remains limited. To this end, the main objective of this study is toinvestigate the role of the ubiquitylation processes in the regulation of SuFu/Gli interaction.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy