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STUDY OF THE TRANSCRIPTIONAL REGULATION OF THE ONCOSUPPRESSOR KCASH2
Vol 32, Issue 4S1, 2018
Abstract
KCTD containing Cullin3 adaptor, suppressor of Hedgehog (KCASH2) belongs to the KCASH familyof proteins, which are involved in the negative regulation of the Sonic Hedgehog (Hh) signaling pathway.All members of KCASH family have shown to be downregulated in Hh dependent Medulloblastoma(Mb), by either allelic loss or promoter methylation. Particularly, KCASH2 expression is reduced alsoin other tumors, not directly connected with Hh pathway modulation; moreover, chromosome 11q,where KCASH2 is localized, is lost in several sporadic tumors. In turn, correlation studies and dataof laboratory show a role of KCASH2 in differentiation and cell cycle regulation, suggesting its fineregulation during development.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy