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EFFECTS OF THE REPURPOSED DRUG CANDIDATE PARBENDAZOLE IN PANCREATIC CANCER CELLS
Vol 32, Issue 4S1, 2018
Abstract
Pancreatic cancer (PC) is the fourth most common cause of cancer death. Classical chemotherapeuticdrugs, used alone or in combination, have a limited advantage in term of 5-year survival, at the cost of arelevant toxicity. Thus, novel therapeutic options with minimal side effects are urgently needed for thislethal disease. In this regard, the use of several non-toxic repurposed drug candidates has been exploredin preclinical models of several tumors. In the present study, we investigated the potential repurposingin PC of the FDA-approved anthelmintic drug parbendazole.
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Supporting Agencies
Copyright (c) 2018 L.DE LELLIS, R. FLORIO, F. VERGINELLI, S. VESCHI, T. DI GENNI, V. DI GIACOMO, S. PAGOTTO, S. CARRADORI, A. CATALDI, A. CAMA
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy