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EFFECT OF OXIDATIVE STRESS ON CANONICAL/NON-CANONICAL WNT PATHWAYS IN COLON CANCER CELL LINES
Vol 32, Issue 4S1, 2018
Abstract
The importance of aberrant regulation of Wnt/β-Catenin signaling in the pathogenesis and colorectalcancer progression has long been recognised. Recent studies have shown that reactive oxygen species(ROS) production activates the Wnt/β-Catenin pathways, but the mechanisms involved remain unclear.Excess in ROS production is linked to chronic inflammation and promotes DNA damages and repairsystems. We aim to evaluate the relationship among oxidative stress response and canonical/noncanonicalWnt pathways in colorectal cancer cell line models with different Wnt signaling behaviour.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy