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INTERPLAY BETWEEN CANNABINOIDS AND INFLAMMATORY CYTOKINES IN HUMAN BREAST CANCER
Vol 32, Issue 4S1, 2018
Abstract
Breast cancer is a highly heterogeneous disease and one of the few tumour types molecularlycharacterized. While luminal and human epidermal growth factor receptor 2 positive (HER2+) tumourscan be controlled by hormonal and anti-HER2 interventions, the triple-negative breast cancers (TNBC)are resistant to standard treatments. Since the tumour microenvironment is an important player in breasttumour progression, the stromal components could represent a source of new prognostic biomarkers andtargets for potential therapeutic strategies mainly in tumors lacking molecular sites of intervention. Wepreviously found that Met-F-AEA, agonist at cannabinoid receptor 1 (CB1) inhibited cell migration andepithelial-mesenchymal transition of the TNBC cell line MDA-MB-231, through modulation of MMP2and Wnt/ß-catenin signaling, respectively.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy