EFFECTS OF HDAC INHIBITORS ON GLIOBLASTOMA CELLS

O. PASTORINO; M.T. GENTILE; A. BAJETTO; A. DI COSTANZO; A. MANCINI; L. ALTUCCI; T. FLORIO; M.P. STOPPELLI; G.

doi:10.54517/jbrha6421

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

EFFECTS OF HDAC INHIBITORS ON GLIOBLASTOMA CELLS

Article ID: 6421
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6421

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Glioblastoma Multiforme (GBM), a high-grade glioma (WHO grade IV), is the most aggressive formof brain cancer. Treatment options for GBM involving a combination of surgery, chemotherapy andradiation resulted in a poor survival outcome. Epigenetic mechanisms are increasingly implicated inGBM pathogenesis. Unlike genetic mutations, epigenetic changes are reversible and can be targetedby drugs. We evaluated whether different Histone Deacetylase Inhibitors (HDACis) are able to affectmigration, invasion and vasculogenic mimicry in GBM cells.

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

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