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A POSSIBLE ROLE OF A CMV-LIKE VIRUS IN HEAD AND NECK PARAGANGLIOMA PATHOGENESIS
Vol 32, Issue 4S1, 2018
Abstract
Paragangliomas (PGLs) are neurovascular autonomic nervous system tumors, still incurable whenradical surgery is not possible. They are frequently associated with susceptibility mutations in genesencoding the mitochondrial SDH complex components. However, the etiology of PGLs remains unclearas the penetrance of SDHx mutations is incomplete (21% at age 50). Studying a large set of freshlycollectedhead and neck PGLs (HNPGLs) by electron microscopy we found herpesvirus-like particles inall tumors. These were similar to particles attributed to cytomegalovirus (HCMV) reported in 1971 byHeine et al. in a retroperitoneal PGL.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy