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PHOSPHODIESTERASE 5 (PDE5) EXPRESSION AND FUNCTION IN BREAST CANCER STROMA: AN ATTRACTIVE OPPORTUNITY FOR TARGETED THERAPY
Vol 32, Issue 4S1, 2018
Abstract
By catalyzing cGMP hydrolysis, phosphodiesterase (PDE) type 5 acts as a critical regulator ofits concentration and effects in different (patho) physiologic processes, including cancers. We havepreviously shown that PDE5 overexpression greatly enhances the invasive potential of breast cancer cellsand reduces survival in patients, highlighting the benefit of therapeutic targeting PDE5. To extend theseobservations, we propose to assess PDE5 function in tumor microenvironment, which has increasinglyknown as an active contributor to breast cancer growth and progression.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy