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BRASSICA EXOSOME-MICRORNAS: NEW THERAPEUTIC APPROACH IN CANCER TREATMENT?
Vol 32, Issue 4S1, 2018
Abstract
Natural medicine has been practiced for centuries and, today, has receiving attentions in bothpharmaceutical industry and academia. Although, many mechanisms of action of plant productsremain unknown, new possible mechanisms are becoming evident: exosomes and their content, miRNAincluded, might regulate gene expression with potential therapeutic activities in human chronic diseases.Plant miRNAs are found in sera and tissues of mammals after plant ingestion, supporting an effectivecommunication between the two kingdoms. In our lab, we have utilized exosomes isolated from Brassicaoleracea sprouts to inhibit the growth of tumor cell lines, as assayed by in vitro wound scratch test andby 3D cultures. To better understand the molecular mechanisms, we performed an in silico study usingthe Brassica miRNA database to predict the human target transcripts. Among others, MIR414 exhibiteda perfect base paring to Spindlin 1 (SPIN1), a human gene upregulated in melanoma cancer
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Supporting Agencies
Copyright (c) 2018 F.M. PEZZINO, A. RUSSO, L. LO CICERO, D. CATALANO, M. PULVIRENTI, B. FICILI, M.C. DI BELLA, L. AMODEO, M.N. TERZO, F. BRANCA
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy