GLUCOSE MODIFIES THE CROSSTALK BETWEEN CANCER CELLS AND ADIPOSE-DERIVED MESENCHYMAL STEM CELLS CONTRIBUTING TO CANCER PROGRESSION


Article ID: 6415
Vol 32, Issue 4S1, 2018
DOI: https://doi.org/10.54517/jbrha6415
Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Hyperglycaemia increases breast cancer (BC) incidence and progression. Glucose may exert its effectson both BC cells and tumour microenvironment. Here, we analysed whether glucose could interfere on thecrosstalk between mammary adipose tissue derived- mesenchymal stem cells (MAT-MSCs) and oestrogenpositive-MCF7 BC cells, thereby modifying MSC phenotype and affecting tumour progression.



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