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ERa DRIVES LKB1 FUNCTIONAL ROLE IN ADIPONECTIN-TREATED BREAST CANCER CELLS
Vol 32, Issue 4S1, 2018
Abstract
Adipose microenvironment is involved in signaling pathways that influence breast cancer developmentand progression, through the secretion of different adipocytokines. Among these, adiponectin plays a pivotalrole in the pathogenesis of breast cancer. An inverse correlation is reported between obesity and adiponectin,suggesting that low levels represent a risk factor for mammary cancer. In the recent years, our researchgroup has identified ERa as an important regulator of adiponectin action in breast cancer, clarifying thatthe role of this adipocytokine seems to be dependent on cell phenotypes. LKB1 is an important target ofadiponectin action, being involved in multiple cellular functions, such as cell metabolism, cell cycle arrest,apoptosis, motility and cell polarity. Here, we investigated the effect of adiponectin on expression andfunction of LKB1 in ERa-positive (MCF-7) and negative (MDA-MB-231) breast cancer cells.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy