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MULTIPOTENCY OF EPICARDIAL ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS IS IMPAIRED IN TYPE 2 DIABETES
Vol 32, Issue 4S1, 2018
Abstract
Excess of visceral fat is a major culprit in the development of type 2 diabetes and related disorders.A growing body of evidence indicates that epicardial adipose tissue (EAT), the visceral fat of the heart,may play an active role in dysregulation of cardiac function. Indeed, EAT thickness positively correlateswith the release of inflammatory molecules and with the severity of heart pathologies. In patientswith diabetes, prolonged hyperglycemia damages several organs, including heart. Thus, potent proinflammatoryactivation of EAT suggests a direct involvement of cardiac visceral fat in inflammatoryphenomena occurring in patients with cardiovascular diseases. This study aims at investigating whetherdifferent glucose concentrations may impact on EAT functions.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy