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ASPECTS OF MELANOMA CELLS ADAPTED TO A CHRONIC ACIDOSIS RELEVANT FOR THERAPY
Vol 32, Issue 4S1, 2018
Abstract
The chaotic and incomplete vasculature of tumor stroma is frequently responsible for a transient and/orpersistent state of hypoxia, and tumor cells adapt their metabolism to anaerobic glycolysis. Therefore, lactateand protons are produced in large excess and transported outside by redundant families of lactate and H+transporters in order to maintain an intracellular pH compatible with survival and/or proliferation. Therefore,the extracellular pH of tumors turns to acidic for a different period of time, conferring new adaptive aspects tocancer cells, characterizing the transient-exposed and chronically-exposed tumor cell subpopulations.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy