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EVALUATION OF ENDOCRINE DISRAPTORS, TPHP AND DPHP, EFFECT ON DNA REPAIR DAMAGE PATHWAIS IN A NORMAL HUMAN THYROID CELL MODEL
Vol 32, Issue 4S1, 2018
Abstract
Thyroid diseases affect about 20% of the Italian Population and thyroid cancer (TC) is the mostcommon endocrine neoplasm. TC incidence showed an increase over the past few years, especially amongwomen. The recent attention of researchers has turned to the possible role of environmental factors ableto interfere as Endocrine Disrupting Chemicals (EDCs) may affect thyroid function. Some EDCs mayplay a role in the etiology of thyroid disorders and increase the risk of TC, based on interactions betweenmetabolic homeostasis and DNA repair systems. Triphenyl phosphate (TPHP) is a commonly used flameretardant and plasticizer the exposure of them were been recently suggested to alter thyroid function.This study investigates the effect of TPhP and its metabolite, diphenyl phosphate (DPhP), on DNA repairand metabolism in a normal human thyroid cells model, Nthy-ori3-1.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy