P27KIP1 IN PSORIASIS. A PRELIMINARY IMMUNOHISTOCHEMICAL STUDY


Article ID: 6409
Vol 32, Issue 4S1, 2018
DOI: https://doi.org/10.54517/jbrha6409
Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Psoriasis, a chronic immune-inflammatory skin disease, is characterized by intense proliferationand abnormal differentiation of keratinocytes. It is a complex multifactorial disease and the exactpathogenesis remains to be elucidated. The cyclin dependent kinase inhibitor p27Kip1 is known to play akey role in cell cycle regulation by controlling the G1 to S phase transition. It is a negative regulator ofcell cycle progression, as well as an inducer of apoptosis. The aim of the present study was to investigatep27Kip1 expression in skin samples from healthy subjects and psoriatic patients.



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