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EFFECT OF BIOCOMPATIBLE EXTRACTS OF OLEA EUROPAEA L. ON OVARIAN CANCER CELLS MODEL
Vol 32, Issue 4S1, 2018
Abstract
Ovarian cancer is characterized by a high mortality rate among gynaecological malignanciesworldwide. Accumulating evidence indicates that impairments of DNA repair and energy metabolismare implicated in the initiation and progression of ovarian cancer (OC). However, the relationshipsamong these aspects are not extensively studied in ovarian cancer physiopathology. The Extracts of Oleaeuropaea L. may be used as a potential source of both antioxidant and anticancer effects, although theconcentration of the phenolic fraction is several times higher in olive leaf than in olive oil and variesdepending on the cultivar and climate. This study investigates the effect, on OC cell model, of phenolicbioactive compounds of Olea europaea L: Verbascoside (VB) and Oleuropein (OL), the two majorbiocompatible extracts from olive leaf and extra-virgin olive oil.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy