HYPOMETHYLATING AGENT 5-AZA-2&rsquo;-DEOXYCYTIDINE (DAC) AMELIORATES THE CLINICAL COURSE OF RHEUMATOID ARTHRITIS IN A MOUSE MODEL

P. FAGONE; K. MANGANO; S. MAMMANA; E. CAVALLI; M.S. BASILE; F. NICOLETTI

doi:10.54517/jbrha6401

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

HYPOMETHYLATING AGENT 5-AZA-2’-DEOXYCYTIDINE (DAC) AMELIORATES THE CLINICAL COURSE OF RHEUMATOID ARTHRITIS IN A MOUSE MODEL

P. FAGONE, K. MANGANO, S. MAMMANA, E. CAVALLI, M.S. BASILE, F. NICOLETTI

Article ID: 6401
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6401

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

Increasing body of data suggest a key role for epigenetics in the etiopathogenesis/development ofautoimmune disorders. Indeed, epigenetic dysregulations have already been described in rheumatoidarthritis (RA), lupus erythematosus (SLE), and multiple sclerosis (MS) patients. Decitabine (5-aza-2’-deoxycytidine, Dacogen, (DAC) is a hypomethylating agent used for the treatment of myelodysplasticsyndrome. We have previously shown that DAC has both prophylactic and therapeutic disease-modifyingproperties in two mouse models of MS.

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Medical Genetics, University of Torino Medical School, Italy

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