ROLE OF KIR AND HLA INTERACTION IN HIV-INFECTED PATIENTS WITH LOWLEVEL VIREMIA

M.E. LIGOTTI; C.M. GAMBINO; A. AIELLO; G. ACCARDI; C. CARUSO; C. COLOMBA; D. DI BONA; G. CANDORE

doi:10.54517/jbrha6395

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ROLE OF KIR AND HLA INTERACTION IN HIV-INFECTED PATIENTS WITH LOWLEVEL VIREMIA

M.E. LIGOTTI, C.M. GAMBINO, A. AIELLO, G. ACCARDI, C. CARUSO, C. COLOMBA, D. DI BONA, G. CANDORE

Article ID: 6395
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6395

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

The impact of host genetic variation on outcome of HIV infection in the absence of combinationantiretroviral therapy (cART) has been well documented. Growing evidence reports relationshipbetween specific killer-cells immunoglobulin-like receptor (KIR) polymorphisms and different HIVprogression in the absence of treatment. The goal of the present study is to determine the association ofKIR genes and their human leukocytes antigen (HLA) ligands with viral load and HIV progression inpatients on cART.

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Medical Genetics, University of Torino Medical School, Italy

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