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TRIGGERING OF TOLL-LIKE RECEPTORS IN THE ELDERLY. A PILOT STUDY RELEVANT FOR VACCINATION
Vol 32, Issue 4S1, 2018
Abstract
Immunosenescence impacts on the immune system of older people leading to an inefficient reactionto pathogens and reduced ability to develop a powerful immune response after vaccination. Recently,research in immunological ageing have suggested that stimulation of Toll-like receptors (TLRs) isa promising strategy to enhance vaccine efficacy in the elderly by activation of innate immune cellsand production of inflammatory cytokines. In this scenario, great importance assume dendritic cells(DCs), the most potent antigen presenting cells, specialized for the uptake, processing, transport andpresentation of antigens to T cells.
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Copyright (c) 2018 C.M. GAMBINO, G. ACCARDI, A. AIELLO, K. IOANNOU, F. FARZANEH, S. VASTO, C. CARUSO, F. GERVASI, G. CANDORE
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy